|
Diagnostic Tool for High-grade Serous Ovarian Cancer - (HJF 616-21)
Researchers at HJF, Inova Fairfax Hospital (IFH), and the Peter MacCallum Cancer Center (PMCC) have identified orthogonal protein and transcript-based biomarkers correlating with Homologous Recombination Deficiency (HRD). This may lead to a companion clinical diagnostic assay to prioritize High-Grade Serous Ovarian Cancer (HGSOC) patients for targeted...
Published: 12/12/2024
|
Updated: 12/12/2024
|
Inventor(s): Nicholas Bateman, Tamara Abulez, Thomas Conrads, George Larry Maxwell, Dale Garsed, David Bowtell, Ahwan Pandey
Keywords(s): Assay, Biomarker Assay, Companion Diagnostic, DDR, DNA Damage Repair, HGSOC, High-Grade Serous Ovarian Carcinoma, Ovarian Cancer, PARP Inhibitors
Category(s): Diagnostics, Therapeutic
|
|
Lymphocyte Antigen 6 (Ly6) Targeted Cancer Immunotherapy (HJF 649-23)
A technology related to using antibodies, antibody-drug conjugates, and chimeric antigen receptor (CAR) transduced immune cells that selectively targets Ly6 family of proteins overexpressed in cancer cells and has the potential to be effective in treating ovarian, colorectal, gastric, breast, and lung cancer without off-target effects. This HJF technology...
Published: 12/12/2024
|
Updated: 5/3/2024
|
Inventor(s): Geeta Upadhyay
Keywords(s): Antibody, Antibody Conjugates, Antibody Drug Conjugate, Cancer, CAR, Ly6, Lymphocite Antigen 6
Category(s): Therapeutic
|
|
Immunogens and Vaccine Components Against HIV - (HJF 630-22)
Henry M. Jackson Foundation (HJF) researchers have developed a novel vaccine strategy against HIV-1. These vaccine candidates are designed to elicit broadly neutralizing antibodies that could protect against a wide variety of HIV strains.
Applications and Advantages
Novel vaccine design approach that emulates the diversity observed in HIV-1 infections...
Published: 11/6/2024
|
Updated: 2/7/2024
|
Inventor(s): Morgane Rolland, Eric Lewitus, Hongjun Bai
Keywords(s): Antibody, Assay, bnAbs, CD4, Env, HIV, Vaccines
Category(s): Vaccine, Therapeutic
|
|
Immunogens and Vaccine Compositions Against Flavivirus - (HJF 624-22)
HJF researchers have developed a novel recombinant flavivirus immunogen that can induce immunogenicity against multiple flaviviruses, including ZIKV (Zika) and DENV (dengue), without life-threatening antibody-dependent enhancement (ADE) responses. Mice immunized with this recombinant immunogen were protected from lethal ZIKV challenge.
Applications...
Published: 12/12/2024
|
Updated: 12/1/2023
|
Inventor(s): Shelly Krebs, Vincent Dussupt
Keywords(s): Dengue, Flavivirus, Immunogen, Vaccines, Zika
Category(s): Diagnostics, Therapeutic
|
|
Predictive Tool on Probability of Successful Wound Closure - (HJF 637-22)
Greater than 20% of traumatic wound closure attempts fail due to the immuno-molecular status of the healing wound tissue.
Researchers at HJF and the Uniformed Services University for Health Sciences (USU) developed a product that analyzes the individual's wound healing immune response and computes a risk of failure score based on cytokine levels...
Published: 12/12/2024
|
Updated: 10/12/2023
|
Inventor(s): Seth Schobel-McHugh, Eric Elster, Henry Robertson, Felipe Lisboa, Michael Rouse, Scott Grey
Keywords(s): Biomarker, CDST, Dehisced Wound, Effluent, Healing, Serum, Wound, Wound Closure, Wound Failure
Category(s): Diagnostics, Medical Devices, Therapeutic, Healthcare IT
|
|
Wound Healing Phototherapy Device - (HJF 288-12)
Technology for a portable, less expensive light-emitting device (LED) that can be used for wound healing at home or as an outpatient treatment option is available for licensing from the Henry M. Jackson Foundation (HJF).
Researchers at HJF, the Nitto Denko Technical Corporation, and the Uniformed Services University have developed an Organic LED (OLED)...
Published: 10/1/2024
|
Updated: 10/12/2023
|
Inventor(s): Juanita Anders, Xingjia Wu, Sazzadur Khan, Sheng Li, Amane Mochizuki
Keywords(s): Diabetes, Phototherapy, Post-Surgical, Wound Closure, Wound Healing, Wound Technology
Category(s): Medical Devices, Therapeutic
|
|
ETV1 Monoclonal Antibodies - (HJF 641-23)
ETV1 is a protein of Erythroblast Transformation Specific (ETS) family of transcription factors. Dysregulation of ETV-1 has been observed in many malignancies including, gastrointestinal stromal (GIS), prostatic tumors, and in triple-negative breast cancer.
Researchers at Henry M. Jackson Foundation (HJF) and Uniformed Services University for Health...
Published: 10/17/2024
|
Updated: 4/5/2023
|
Inventor(s): Shyh-Han Tan, Albert Dobi, Shiv Srivastava
Keywords(s): ERG, Monoclonal Antibodies, Prostate Cancer
Category(s): Diagnostics, Research Tool, Therapeutic
|
|
Vaccines Against Fentanyl and Fentanyl Analogs - (HJF 561-19)
A technology related to novel fentanyl hapten compounds and their use in the preparation of vaccines against fentanyl and fentanyl analogs is available for licensing.
Applications and Advantages
Novel compounds for use as vaccines against fentanyl and analogs
High immunogenicity that generates fentanyl specific antibodies to reduce its distribution...
Published: 10/17/2024
|
Updated: 3/27/2023
|
Inventor(s): Gary Matyas, Oscar Torres, Kenner Rice, Eric Bow, Agnieszka Sulima, Arthur Jacobson
Keywords(s): Antibody, Diagnostics, Fentanyl, Therapeutics, Vaccines
Category(s): Diagnostics, Therapeutic, Vaccine
|
|
Compositions and Methods for Producing Protein Vaccines and Therapeutics - (HJF 165-07)
A technology related to compositions and methods for making protein vaccines or therapeutics is available for licensing from the Henry M. Jackson Foundation (HJF).
This invention provides a novel composition that, when cellular extracts or whole cells are irradiated, protects cellular protein structure and function while DNA molecules are broken down....
Published: 11/6/2024
|
Updated: 3/27/2023
|
Inventor(s): Michael Daly, Elena Gaidamakova, Vera Matrosova, Rodney Levine, Nancy Wehr, Sandip Datta, Ian Myles, Cedar Fowler, Patricia Valdez
Keywords(s): Healthcare, Prevention, Therapeutics, Vaccines
Category(s): Radioprotection Technologies, Vaccine, Therapeutic
|
|
Compositions and Methods for Reducing Local and Systemic Risks of Venom - (HJF 467-17)
Envenomation is the process of venom being injected through a bite or a sting, by a variety of sources such as snakes, wasps, jelly fish, scorpions, spiders etc. Administering an antivenom is the most effective treatment option. However, access to treatment and affordability is a challenge, especially in rural areas that have high incidence rates.
A...
Published: 5/6/2024
|
Updated: 3/22/2023
|
Inventor(s): Angela Jockheck-Clark
Keywords(s): Antivenom, Envenomation, Spreading Factors, Venom
Category(s): Therapeutic
|