Henry M. Jackson Foundation for the Advancement of Military Medicine

Advancing Military Medicine

Search Results - antibody

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Lymphocyte Antigen 6 (Ly6) Targeted Cancer Immunotherapy (HJF 649-23)
A technology related to using antibodies, antibody-drug conjugates, and chimeric antigen receptor (CAR) transduced immune cells that selectively targets Ly6 family of proteins overexpressed in cancer cells and has the potential to be effective in treating ovarian, colorectal, gastric, breast, and lung cancer without off-target effects. This HJF technology...
Published: 12/12/2024   |   Updated: 5/3/2024   |   Inventor(s): Geeta Upadhyay
Keywords(s): Antibody, Antibody Conjugates, Antibody Drug Conjugate, Cancer, CAR, Ly6, Lymphocite Antigen 6
Category(s): Therapeutic
Immunogens and Vaccine Components Against HIV - (HJF 630-22)
Henry M. Jackson Foundation (HJF) researchers have developed a novel vaccine strategy against HIV-1. These vaccine candidates are designed to elicit broadly neutralizing antibodies that could protect against a wide variety of HIV strains. Applications and Advantages Novel vaccine design approach that emulates the diversity observed in HIV-1 infections...
Published: 11/6/2024   |   Updated: 2/7/2024   |   Inventor(s): Morgane Rolland, Eric Lewitus, Hongjun Bai
Keywords(s): Antibody, Assay, bnAbs, CD4, Env, HIV, Vaccines
Category(s): Vaccine, Therapeutic
Vaccines Against Fentanyl and Fentanyl Analogs - (HJF 561-19)
A technology related to novel fentanyl hapten compounds and their use in the preparation of vaccines against fentanyl and fentanyl analogs is available for licensing. Applications and Advantages Novel compounds for use as vaccines against fentanyl and analogs High immunogenicity that generates fentanyl specific antibodies to reduce its distribution...
Published: 10/17/2024   |   Updated: 3/27/2023   |   Inventor(s): Gary Matyas, Oscar Torres, Kenner Rice, Eric Bow, Agnieszka Sulima, Arthur Jacobson
Keywords(s): Antibody, Diagnostics, Fentanyl, Therapeutics, Vaccines
Category(s): Diagnostics, Therapeutic, Vaccine
Antibody Based Therapy for HIV - (HJF 562-20)
Currently, anti-retroviral therapy (ART) based on controlling viral replication is the most effective treatment for HIV. However, HIV drug resistance can compromise the effectiveness of ART. Researchers at Uniformed Services University of Health Sciences (USU) and Henry M Jackson Foundation (HJF) in collaboration with scientists at Université...
Published: 5/6/2024   |   Updated: 1/23/2023   |   Inventor(s): Marzena Pazgier, William Tolbert, Dung Nguyen, Andres Finzi, Jonathan Richard
Keywords(s): Antibody, Antibody Conjugates, CD4, Cytotoxicity, HIV, Neutralization, Peptide-Based Mimetic Compounds
Category(s): Therapeutic, Antibody Therapy
Shark Antibodies and Shark-Derived Binding Domains Specific for the SARS-CoV-2 Coronavirus - (HJF 581-20)
HJF scientists have developed a series of single variable domain antibodies (nanobodies or VNARs, derived from nurse sharks) specifically targeting SARS-CoV-2 and other betacoronaviruses, thus providing unique therapeutics and diagnostics for COVID-19 and possibly other betacoronavirus infections. Applications and Advantages Fully sequenced, grafted...
Published: 10/17/2024   |   Updated: 5/20/2022   |   Inventor(s): Michael Gordon Joyce, Kayvon Modjarrad, Helen Dooley
Keywords(s): Antibody, Coronavirus, COVID-19, Diagnostics, Sarbecovirus, SARS-CoV-2, Therapeutics
Category(s): Therapeutic, Diagnostics