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Vaccines Against Fentanyl and Fentanyl Analogs - (HJF 561-19)
A technology related to novel fentanyl hapten compounds and their use in the preparation of vaccines against fentanyl and fentanyl analogs is available for licensing.
Applications and Advantages
Novel compounds for use as vaccines against fentanyl and analogs
High immunogenicity that generates fentanyl specific antibodies to reduce its distribution...
Published: 10/17/2024
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Updated: 3/27/2023
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Inventor(s): Gary Matyas, Oscar Torres, Kenner Rice, Eric Bow, Agnieszka Sulima, Arthur Jacobson
Keywords(s): Antibody, Diagnostics, Fentanyl, Therapeutics, Vaccines
Category(s): Diagnostics, Therapeutic, Vaccine
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Compositions and Methods for Producing Protein Vaccines and Therapeutics - (HJF 165-07)
A technology related to compositions and methods for making protein vaccines or therapeutics is available for licensing from the Henry M. Jackson Foundation (HJF).
This invention provides a novel composition that, when cellular extracts or whole cells are irradiated, protects cellular protein structure and function while DNA molecules are broken down....
Published: 11/6/2024
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Updated: 3/27/2023
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Inventor(s): Michael Daly, Elena Gaidamakova, Vera Matrosova, Rodney Levine, Nancy Wehr, Sandip Datta, Ian Myles, Cedar Fowler, Patricia Valdez
Keywords(s): Healthcare, Prevention, Therapeutics, Vaccines
Category(s): Radioprotection Technologies, Vaccine, Therapeutic
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Small Molecule Targeted Therapeutics for Breast Cancer - (HJF 533-19)
A technology related to using novel small molecule therapeutics for breast cancer treatment is available for licensing from HJF. These small molecules specifically inhibit LY6K, a cancer-testis oncoprotein, in cancer cells, thus providing a novel targeted therapy for breast, colorectal, and other cancers.
Applications and Advantages
Targeted therapeutics...
Published: 10/17/2024
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Updated: 1/23/2023
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Inventor(s): Geeta Upadhyay
Keywords(s): Breast Cancer, Cancer, Colorectal Cancer, LY6K, Oncogene, Small Molecule, Therapeutics
Category(s): Therapeutic
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Novel Therapeutics for Graft-Versus-Host Disease - (HJF 383-14)
A technology related to novel therapeutics for treating graft-versus-host disease (GvHD) is available for licensing from HJF. In vivo animal studies have shown its efficacy in reducing infiltrating inflammatory T cells in the colon as well as reduction of GvHD-associated weight loss and mortality.
Applications and Advantages
Novel protein therapeutics...
Published: 5/6/2024
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Updated: 1/13/2023
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Inventor(s): Gabriela Dveksler, Elizabeth Kang, Karlie Sharma
Keywords(s): Therapeutics
Category(s): Therapeutic
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Malaria Vaccine - (HJF 474-17)
A novel composition of malaria vaccine technology is available for licensing from HJF. A Phase I clinical trial has been completed and results have shown the safety and efficacy of this vaccine composition in humans.
Applications and Advantages
Novel immunogens and compositions for malaria vaccine
Significant clinical efficacy demonstrated in humans
Fully...
Published: 11/6/2024
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Updated: 12/1/2022
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Inventor(s): Zoltan Beck, Carl Alving, Gary Matyas, Sheetij Dutta
Keywords(s): Infectious Disease, Malaria, Prevention, Therapeutics, Vaccines
Category(s): Therapeutic, Vaccine
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Targeted Therapeutics for Treating Sickle Cell Disease and β-thalassemia - (HJF 596-21)
Novel therapeutics for sickle cell disease and β-thalassemia are available for licensing and collaboration. This technology was developed by scientists from the Uniformed Services University of Health Sciences and assigned to HJF.
Applications and Advantages
Novel therapeutic targets for sickle cell disease and β-thalassemia.
Several...
Published: 10/17/2024
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Updated: 6/28/2022
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Inventor(s): Yang (Dennis) Du
Keywords(s): Sickle Cell Disease, Therapeutics, β-globinopathies, β-thalassemia
Category(s): Therapeutic
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Shark Antibodies and Shark-Derived Binding Domains Specific for the SARS-CoV-2 Coronavirus - (HJF 581-20)
HJF scientists have developed a series of single variable domain antibodies (nanobodies or VNARs, derived from nurse sharks) specifically targeting SARS-CoV-2 and other betacoronaviruses, thus providing unique therapeutics and diagnostics for COVID-19 and possibly other betacoronavirus infections.
Applications and Advantages
Fully sequenced, grafted...
Published: 10/17/2024
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Updated: 5/20/2022
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Inventor(s): Michael Gordon Joyce, Kayvon Modjarrad, Helen Dooley
Keywords(s): Antibody, Coronavirus, COVID-19, Diagnostics, Sarbecovirus, SARS-CoV-2, Therapeutics
Category(s): Therapeutic, Diagnostics
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Peptide Vaccine for Preventing Recurrence of Ovarian or Endometrial Cancer - (HJF 593-21, HJF 592-21)
Preventing cancer recurrence remains an unmet clinical need. A cancer peptide vaccine technology, available from HJF for licensing, has shown significant clinical efficacy in preventing and reducing the risk of recurrence of ovarian and endometrial cancers.
Applications and Advantages
Significant clinical efficacy demonstrated in human studies
Personalized...
Published: 5/6/2024
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Updated: 5/19/2022
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Inventor(s): George Peoples
Keywords(s): Cancer Vaccine, Endometrial Cancer, Oncology, Ovarian Cancer, Therapeutics
Category(s): Therapeutic
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Small Molecule Inhibitors of ERG Oncoprotein - (HJF 578-20, HJF 393-15, and HJF 324-13)
HJF scientists have developed a first-in-class family of novel and potent small molecule ERG inhibitors that can be used as targeted therapeutics for malignant diseases with overexpression of ERG oncoproteins. Therapeutic indications may include prostate cancer, leukemia, and colorectal cancer.
Applications and Advantages
First-in-class small molecule...
Published: 10/17/2024
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Updated: 3/8/2022
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Inventor(s): Albert Dobi, Sanjay Malhotra, Mallesh Pandrala, Binil Eldhose
Keywords(s): Cancer, Colorectal Cancer, ERG, Leukemia, Oncogene, Prostate Cancer, Small Molecule, Therapeutics
Category(s): Therapeutic
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